Therapeutic intent salvage chemotherapy prior to bone marrow transplant bmt. Description of current practices of empiric chemotherapy dose adjustment in obese adult patients. In patients with relapsed lymphomas, ice has achieved a 66%. Ice chemotherapy, with ifosfamide administered as a 24hour infusion to decrease cns side effects, and the substitution of carboplatin for cisplatin to minimize nephrotoxicity, is a very effective cytoreduction and mobilization regimen in patients with nhl. Putting chemotherapy side effects on ice cancer today. Ice in the context of chemotherapy is an acronym for one of the chemotherapy regimens, used in salvage treatment of relapsed or refractory nonhodgkins lymphoma and hodgkin lymphoma. As we strive to keep these documents uptodate, revisions are. New contracts and growing interest in the uk highlight strong potential for newly acquired software.
Ice most often associated with treatment of nonhodgkins lymphoma. Ice chemotherapy is a common form of treatment for several types of white blood cell cancers called nonhodgkins lymphomas. Premedication with acetaminophen and diphenhydramine recommended prior to first dose and dose escalations. Outpatientbased ifosfamide, carboplatin and etoposide. Anyways, i will be starting rice chemotherapy march 6th and will do either 2 or 3 rounds of it until i have a date for when i start. Cycles of ice therapy were administered every 21 days as an outpatient and consisted of ifosfamide 5000 mgm2 intravenously i.
In case of cd20positive b cell lymphoid malignancies the ice regimen is often combined today with rituximab. Day medication dose route administration details 1. Bc cancer systemic therapy program has placed summaries of specific treatment protocols on the website. Chemotherapy for ewing tumors american cancer society. Did salvage ice chemotherapy improve the outcome in. One of the biggest challenges oncology clinics face is ensuring orders are documented properly and regimens are followed accurately, since there are significant consequences. Combinations usually work better than single drugs because different drugs kill cancer cells in different ways. Pdf outpatientbased ifosfamide, carboplatin and etoposide ice.
Doctors have long employed maintenance therapy in management of cancer cases. Chemotherapy often abbreviated to chemo and sometimes ctx or ctx is a type of cancer treatment that uses one or more anticancer drugs chemotherapeutic agents as part of a standardized. Rice chemotherapy is a regimen used to treat lymphoma cancers, which affect b cells. Ice chemotherapy treatment is used for nonhodgkin lymphoma. Chemotherapy dosing is typically individualized based on the patients body surface.
Rice chemotherapy with or without autologous transplantation for. Mediwares new chemotherapy software realizes early. How much chemotherapy agent should be administered to a patient. The acronym is derived from the names of the three drugs. This regimen includes a combination of four different chemotherapy drugs. In the literature, patients received ice at lower dosages and achieved major response rates 36% in phase 1 and 2 studies in which less comprehensive staging evaluations were used that involved resistant nb and 70% in induction for newly diagnosed nb. At cancer treatment centers of america ctca, we work closely with our. The combination of ifosfamide, carboplatin, and etoposide ice has been used for relapse and.
Unfortunately my cancer is just as stubborn as i am. Once rice chemo is complete, it is often followed by an autologous stem cell transplant stems cells from yourself, and is commonly given with the goal of cure. Because renal function may change through a course of chemotherapy, this calculation should be repeated prior to each dose of carboplatin. Nonhodgkin lymphoma ice infusional ifosfamide carboplatin etoposide. Before starting the treatment blood test is necessary. A previous study by ishiguro, though, showed that degree of.
Chemotherapyrefractory bcell chronic lymphocytic leukemia. This diet includes milk, yogurt without fruit pieces, ice cream, sherbet, milkshakes, strained cream soups, hot. The time of infusion varies depending upon tolerability. There are different regimens, but maintenance therapy is almost always milder and less stressful on the body than first. Outpatient fractionated ifosfamide, carboplatin and etoposide as. A prospective study of all patients treated with chemotherapy over a 12month period was performed. The following material represents a subset of chemotherapy and immunotherapy regimens that are used for the treatment of patients with lymphoma. The gloves and socks are stored inside a freezer set at 22 degrees fahrenheit for more than three hours, typically overnight. Does anyone have any insights or experience with ice chemotherapy that youd care to share.
Hodgkins lymphoma patients will not receive rituximab as. Fda clears wider use of cooling cap to reduce hair loss. A 2step comprehensive highdose chemoradiotherapy secondline. Implementation of a pharmacymanaged program for the transition of chemotherapy to the. Chemo orders and consents penn state cancer institute. These summaries are those in current use by the systemic therapy program staff at all. Dose augmented rituximab and ice for pts with primary refractory. Outpatient fractionated ice protocol in relapsedrefractory. The list of disease and specialty groups below are links to available chemotherapy orders and consents frequently used in their treatment. Its the recommended treatment for my 83 year old mother, whos battling both hodgkins and nonhodgkins. Chemotherapy is often given as a combination of drugs. Oncology is a complex specialty with unique terminology and protocols, especially when it comes to ordering and administering chemotherapy. The template automatically pulls in identifiers and allergies. Nonhodgkin lymphoma ice infusional ifosfamide carboplatin etoposide haemorrhagic cystitis.
Ice chips may help some people undergoing chemotherapy eat better, according to a new study oxaliplatin eloxatin is a chemotherapy drug used mainly to treat gastrointestinal cancers. Interventions in the improving chemotherapy ordering process project reduced the number of order forms with deviations by % by june 20. An electronic chemotherapy ordering process and template. Ice chemotherapy, with ifosfamide administered as a 24hour infusion to decrease cns side effects, and the substitution of carboplatin for cisplatin to minimize nephrotoxicity, is a very. Ice chemotherapy is standard chemotherapy used at memorial. Carboplatin auc dose calculation calvert formula calculator.
Ice as salvage treatment prior to high dose chemotherapy and. Dose augmented rituximab and ice for pts with primary refractory and poor risk relapsed aggressive bcell nhl the safety and scientific validity of this study is the responsibility of. When the provider engages the dedicated progress note, the more complex of the 2 templates engages. Experience with computerized chemotherapy order entry. This is sometimes called a venous access device vad or central venous catheter cvc. Diets that you may follow during chemotherapy treatments. Lenexa, ks august 15, 2012 mediware information systems, inc. Now a study from researchers at the university of pennsylvania in philadelphia shows that there may be a nocost way to mitigate. In our study, the ratio of patients with chemotherapy dose reduction less than 30% was. Description of current practices of empiric chemotherapy. It is a treatment for hodgkin and nonhodgkin lymphoma that has come back. Cancer patients are at high risk for developing drug toxicity due to the low therapeutic index of the. Rice chemotherapy with or without autologous transplantation for elderly.
Chemotherapy is the treatment of cancer with drugs that can destroy cancer cells by impeding their growth and reproduction. Chemotherapy by ice for primary resistant or progressive stage iiiiv nb seems well tolerated. Many types of chemo are given as an infusion or injection. Of the i i follicular lymphoma patients, 10 also received rituximab with ice therapy. Determining the appropriate dose of a chemotherapy agent. Ice nonhodgkin lymphoma chemotherapy regimen doctors. With chemo infusions, chemotherapy drugs are put into your body through a thin tube called a catheter thats placed in a vein, artery, body cavity, or.
Questions about rice chemotherapy cancer survivors network. Dose augmented rituximab and ice for pts with primary. Chemotherapeutic agents and their uses, dosages, and. Each of the drugs in this combination is approved by the food and drug administration fda to treat cancer or conditions related to cancer. We want to help everyone with cancer live life as fully as they can. Ifosfamide, carboplatin, and etoposide for neuroblastoma. Frozen gloves and socks help reduce chemotherapyinduced. In dose banding, patients are classified according to their bsa into predefined ranges. Hodgkins lymphoma patients will not receive rituximab as below. Soon after the ewing tumor is diagnosed but before starting chemo, the doctor may suggest surgery to put a catheter a thin, soft tube into a large vein in the patients chest. Fractionated ice with rituximab is safe and effective for. Chemotherapy comes with numerous unpleasant and painful side effects. Comparison of ice ifosfamidecarboplatinetoposide versus dhap cytosine arabinosidecisplatindexamethasone as salvage chemotherapy in patients with relapsed or refractory lymphoma. Outpatient fractionated ice protocol in relapsedrefractory lymphomas.